Parkinson's disease: depletion of substantia nigra neurotensin receptors

G. R. Uhl, P. J. Whitehouse, D. L. Price, W. W. Tourtelotte, M. J. Kuhar

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalBrain research
Volume308
Issue number1
DOIs
StatePublished - Aug 6 1984

Keywords

  • Parkinson's disease
  • neurotensin
  • peptide
  • receptor autoradiography
  • substantia nigra

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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