Parkinson's disease and mitochondrial gene variations: A review

Sasan Andalib; Manouchehr Seyedi Vafaee; Albert Gjedde

doi:10.1016/j.jns.2014.07.067

Parkinson's disease and mitochondrial gene variations: A review

Sasan Andalib, Manouchehr Seyedi Vafaee, Albert Gjedde

School of Medicine

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.

Original language	English (US)
Pages (from-to)	11-19
Number of pages	9
Journal	Journal of the Neurological Sciences
Volume	346
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2014.07.067
State	Published - Nov 15 2014

Keywords

Central nervous system
Genetic susceptibility
Mitochondrial DNA nucleotide position
Mitochondrial DNA variations
Mitochondrial dysfunction
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2014.07.067

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title = "Parkinson's disease and mitochondrial gene variations: A review",

abstract = "Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.",

keywords = "Central nervous system, Genetic susceptibility, Mitochondrial DNA nucleotide position, Mitochondrial DNA variations, Mitochondrial dysfunction, Parkinson's disease",

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T2 - A review

AU - Andalib, Sasan

AU - Vafaee, Manouchehr Seyedi

AU - Gjedde, Albert

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Y1 - 2014/11/15

N2 - Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.

AB - Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.

KW - Central nervous system

KW - Genetic susceptibility

KW - Mitochondrial DNA nucleotide position

KW - Mitochondrial DNA variations

KW - Mitochondrial dysfunction

KW - Parkinson's disease

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Parkinson's disease and mitochondrial gene variations: A review

Abstract

Keywords

ASJC Scopus subject areas

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