Parental history of Type 2 diabetes in patients with nonaffective psychosis

Emilio Fernandez-Egea, Brian Miller, Miguel Bernardo, Thomas Donner, Brian Kirkpatrick

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Introduction: We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands. Methods: N = 34 patients with newly-diagnosed nonaffective psychosis and N = 52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes. Results: In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p < 0.04). Discussion: We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalSchizophrenia Research
Issue number1-3
StatePublished - Jan 2008
Externally publishedYes


  • Epidemiology
  • Family history
  • Nonaffective psychosis
  • Schizophrenia
  • Type 2 diabetes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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