Paraneoplastic pemphigus: A report of two patients responding to cyclosporin

M. Stahle-Backdahl, M. A. Hedblad, C. Skoglund, P. Fagerholm, G. J. Anhalt

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21 Scopus citations


Paraneoplastic pemphigus is a distinct, autoimmune, mucocutaneous disease associated with malignancy. We report on two patients with chronic lymphocytic leukemia who developed characteristic clinical and immunopathological features of paraneoplastic pemphigus. Both patients were treated with a combination of cyclosporin 3-5 mg/kg, prednisone 0.1-0.4 mg/kg and cyclophosphamide 1-2 mg/kg. The patients responded to therapy and one year after diagnosis both patients are alive with no skin symptoms, but with persisting low-grade inflammation of the mucous membranes and still undergoing immunosuppressive treatment.

Original languageEnglish (US)
Pages (from-to)671-675
Number of pages5
JournalEuropean Journal of Dermatology
Issue number8
StatePublished - Dec 1 1995
Externally publishedYes


  • bullous disease
  • chronic lymphocytic leukemia
  • lichenoid dermatitis
  • paraneoplastic pemphigus

ASJC Scopus subject areas

  • Dermatology


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