Paraneoplastic chorea with leukoencephalopathy presenting with obsessive-compulsive and behavioral disorder

Susanne Muehlschlegel, Michael S. Okun, Kelly D. Foote, Dominique Coco, Anthony T. Yachnis, Hubert H. Fernandez

Research output: Contribution to journalArticlepeer-review

Abstract

Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP-5 antibodies. Obsessive-compulsive disorder and large-scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive-compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed.

Original languageEnglish (US)
Pages (from-to)1523-1527
Number of pages5
JournalMovement Disorders
Volume20
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • CV2 paraneoplastic antibodies
  • Leukoencephalopathy
  • Obsessive-compulsive disorder
  • Paraneoplastic chorea

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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