TY - JOUR
T1 - Paraben exposures and asthma-related outcomes among children from the US general population
AU - Quirós-Alcalá, Lesliam
AU - Hansel, Nadia N.
AU - McCormack, Meredith C.
AU - Matsui, Elizabeth C.
N1 - Funding Information:
L.Q.-A. was supported by a National Heart, Lung, and Blood Institute (NHLBI) Career Development Award (K01HL138124); N.N.H. was supported by the National Institute of Environmental Health Sciences (NIEHS; P50 ES018176 , R01ES022607 , and R01ES023500 ), the National Institute on Minority Health and Health Disparities (NIMHD; ( P50MD010431 ), and the US Environmental Protection Agency (EPA; agreements 83615201 , 83451001 , and 83615001 ); M.C.M. was supported by the NIEHS ( P50 ES018176 and R21 ES025840 ), NIMHD ( P50MD010431 ), and EPA (agreement 83615201); and E.C.M. was supported by the National Institute of Allergy and Infectious Diseases (NIAID; K24AI114769 ) and NIEHS ( R01ES023447 and R01ES026170 ). The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position or views of the National Institutes of Health or the EPA.
Publisher Copyright:
© 2018 American Academy of Allergy, Asthma & Immunology
PY - 2019/3
Y1 - 2019/3
N2 - Background: Parabens are synthetic preservatives present in many consumer products. Their antimicrobial and endocrine-disrupting properties have raised concerns that they might play a role in respiratory and allergic diseases; however, studies exploring these associations are scarce. Objective: We examined the cross-sectional association between parabens and asthma morbidity among 450 children with asthma and with asthma prevalence among 4023 children in the US general population participating in the National Health and Nutrition Examination Survey (2005-2014). Methods: We conducted multivariable logistic regression to examine associations between urinary paraben biomarker concentrations (butyl paraben, ethyl paraben, methyl paraben [MP], and propyl paraben [PP]) and asthma attacks and emergency department visits among children with asthma and with a current asthma diagnosis among all children. We also examined heterogeneity of associations by sex. Results: We observed an increased prevalence odds of reporting emergency department visits for every 10-fold increase in MP and PP concentrations among boys with asthma (adjusted prevalence odds ratio, 2.61 [95% CI, 1.40-4.85] and 2.18 [95% CI, 1.22-3.89, respectively; P interaction-MP = .002 and P interaction-PP = .003); associations remained after adjusting for other phenolic compounds previously linked to respiratory outcomes. No other dimorphic effects of exposure by sex were observed. Among children in the general population, no overall associations with current asthma were observed, although there was a positive trend with PP and a current asthma diagnosis. Conclusion: We identified differential effects of exposure to select parabens by sex on asthma morbidity. Further studies are needed to replicate these findings and elucidate mechanisms by which parabens could affect respiratory health and elicit dimorphic effects by sex.
AB - Background: Parabens are synthetic preservatives present in many consumer products. Their antimicrobial and endocrine-disrupting properties have raised concerns that they might play a role in respiratory and allergic diseases; however, studies exploring these associations are scarce. Objective: We examined the cross-sectional association between parabens and asthma morbidity among 450 children with asthma and with asthma prevalence among 4023 children in the US general population participating in the National Health and Nutrition Examination Survey (2005-2014). Methods: We conducted multivariable logistic regression to examine associations between urinary paraben biomarker concentrations (butyl paraben, ethyl paraben, methyl paraben [MP], and propyl paraben [PP]) and asthma attacks and emergency department visits among children with asthma and with a current asthma diagnosis among all children. We also examined heterogeneity of associations by sex. Results: We observed an increased prevalence odds of reporting emergency department visits for every 10-fold increase in MP and PP concentrations among boys with asthma (adjusted prevalence odds ratio, 2.61 [95% CI, 1.40-4.85] and 2.18 [95% CI, 1.22-3.89, respectively; P interaction-MP = .002 and P interaction-PP = .003); associations remained after adjusting for other phenolic compounds previously linked to respiratory outcomes. No other dimorphic effects of exposure by sex were observed. Among children in the general population, no overall associations with current asthma were observed, although there was a positive trend with PP and a current asthma diagnosis. Conclusion: We identified differential effects of exposure to select parabens by sex on asthma morbidity. Further studies are needed to replicate these findings and elucidate mechanisms by which parabens could affect respiratory health and elicit dimorphic effects by sex.
KW - Parabens
KW - antimicrobials
KW - asthma
KW - children
KW - endocrine disruptors
KW - respiratory
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U2 - 10.1016/j.jaci.2018.08.021
DO - 10.1016/j.jaci.2018.08.021
M3 - Article
C2 - 30194988
AN - SCOPUS:85054565375
SN - 0091-6749
VL - 143
SP - 948-956.e4
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -