Pancreatic surgery: Evolution at a high-volume center

Kathryn M. Ziegler, Attila Nakeeb, Henry A. Pitt, C. Max Schmidt, Sarah N. Bishop, Jose Moreno, Jesus M. Matos, Nicholas J. Zyromski, Michael G. House, James A. Madura, Thomas J. Howard, Keith D. Lillemoe

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background: Advances in imaging, minimally invasive techniques, and regionalization have changed pancreatic surgery. Therefore, the aims of this report are to determine whether the pancreatic operations or the spectrum of disease have evolved at a high-volume center. Methods: From 1996 through 2009, 2,004 pancreatic operations were performed at Indiana University Hospital. The operations, pathology, and outcomes for 1996-2003 were compared with 2004-2009. Results: In 2004-2009, more operations/year were performed (215 vs 89; P < .01) and patients were older (58.8 years vs 55.8 years; P < .01). In recent years, more pancreatoduodenectomies (55.0% vs 50.4%) and fewer pancreatojejunostomies (6.2% vs 12.6%) and Beger/Frey procedures (2.6% vs 4.8%) were performed (P < .05). In 2004-2009, pylorus preservation (81.1% vs 64.4%), laparoscopic distal pancreatectomy (33.9% vs 0%), and splenic preservation (25.3% vs 2.2%) were carried out more frequently (P < .001). Pathology review revealed more tumors (68.8% vs 60.4%) and less pancreatitis (29.2% vs 34.4%; P < .01). Thirty-day mortality improved from 2.5% to 1.8%. Conclusion: At a high-volume pancreatic surgery center, the number and age of the patients, the percentage of pancreatic resections, preservation of the pylorus and spleen as well as laparoscopic procedures, and the percentage of patients with tumors all have increased, whereas the outcomes continued to improve.

Original languageEnglish (US)
Pages (from-to)702-710
Number of pages9
Issue number4
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Surgery


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