@article{f185f1b7deb649db9ae7fdad5ec76588,
title = "Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop",
abstract = "A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.",
keywords = "central sensitization, pancreatic cancer, pancreatitis, peripheral sensitization, placebo, quantitative sensory testing",
author = "Aliye Uc and Dana Andersen and Apkarian, {A. Vania} and Bellin, {Melena D.} and Luana Colloca and Drewes, {Asbj{\o}rn M.} and Dunbar, {Ellyn K.} and Forsmark, {Christopher E.} and Goodman, {Marc T.} and Leonardo Kapural and Koob, {George F.} and Palermo, {Tonya M.} and Pandol, {Stephen J.} and Pasricha, {Pankaj Jay} and Phillips, {Anna E.} and Daniele Piomelli and Saloman, {Jami L.} and Schwarzenberg, {Sarah Jane} and Singh, {Vikesh K.} and Gwendolyn Sowa and Thomas Strouse and Treisman, {Glenn J.} and Windsor, {John A.} and Dhiraj Yadav",
note = "Funding Information: The Back Pain Consortium (BACPAC) Research Program is administered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and part of the NIH HEAL Network. Funding Information: Funding for the workshop was provided by National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Funding Information: A.U. is a member of the American Board of Pediatrics, Subboard of Pediatric Gastroenterology; a member of the American Pancreatic Association Governing Board; an associate editor of the Pancreatology; and a consultant of the Cystic Fibrosis Foundation. M.D.B. is a consultant/DSMB member of the Insulet and received research support from ViaCyte and Dexcom. C.E.F. is a consultant of Nestle, received research support from AbbVie, and a board member of the National Pancreas Foundation. L.K. received research support from Medtronic, Nevro, Gimer, Neuros, and SPR Therapeutics; a member of the scientific advisory board of Biotronik and Nalu; and a consultant of Avanos, Nevro, and Nalu. The other authors declare no conflict of interest. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",
year = "2021",
month = aug,
day = "1",
doi = "10.1097/MPA.0000000000001899",
language = "English (US)",
volume = "50",
pages = "906--915",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "7",
}