Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies

Daniel Abate-Daga; Steven A. Rosenberg; Richard A. Morgan

doi:10.4161/onci.29194

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies

Daniel Abate-Daga, Steven A. Rosenberg, Richard A. Morgan

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development of immunotherapies, and potential strategies to circumvent ontarget/ off-tumor toxicities.

Original language	English (US)
Article number	e29194
Journal	OncoImmunology
Volume	3
Issue number	6
DOIs	https://doi.org/10.4161/onci.29194
State	Published - 2014

Keywords

Adoptive immunotherapy
Chimeric antigen receptors (CAR)
PSCA
Pancreatic cancer
Synthetic biology

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/onci.29194

Cite this

@article{d737b31e68fe4097b7af714c55ae100a,

title = "Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies",

abstract = "Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development of immunotherapies, and potential strategies to circumvent ontarget/ off-tumor toxicities.",

keywords = "Adoptive immunotherapy, Chimeric antigen receptors (CAR), PSCA, Pancreatic cancer, Synthetic biology",

author = "Daniel Abate-Daga and Rosenberg, {Steven A.} and Morgan, {Richard A.}",

year = "2014",

doi = "10.4161/onci.29194",

language = "English (US)",

volume = "3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "6",

}

TY - JOUR

T1 - Pancreatic cancer

T2 - Hurdles in the engineering of CAR-based immunotherapies

AU - Abate-Daga, Daniel

AU - Rosenberg, Steven A.

AU - Morgan, Richard A.

PY - 2014

Y1 - 2014

N2 - Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development of immunotherapies, and potential strategies to circumvent ontarget/ off-tumor toxicities.

AB - Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development of immunotherapies, and potential strategies to circumvent ontarget/ off-tumor toxicities.

KW - Adoptive immunotherapy

KW - Chimeric antigen receptors (CAR)

KW - PSCA

KW - Pancreatic cancer

KW - Synthetic biology

UR - http://www.scopus.com/inward/record.url?scp=84906517258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906517258&partnerID=8YFLogxK

U2 - 10.4161/onci.29194

DO - 10.4161/onci.29194

M3 - Article

C2 - 25083334

AN - SCOPUS:84906517258

SN - 2162-4011

VL - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 6

M1 - e29194

ER -

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this