TY - JOUR
T1 - Pancreatic cancer genomics
T2 - Insights and opportunities for clinical translation
AU - Makohon-Moore, Alvin
AU - Brosnan, Jacqueline A.
AU - Iacobuzio-Donahue, Christine A.
N1 - Funding Information:
This work was supported by NIH/NCI grants 140599, CA101955, CA62624 and CA121113, The Skip Viragh Pancreatic Cancer Center and The Sol Goldman Pancreatic Cancer Research Center.
PY - 2013/3/28
Y1 - 2013/3/28
N2 - Pancreatic cancer is a highly lethal tumor type for which there are few viable therapeutic options. It is also caused by the accumulation of mutations in a variety of genes. These genetic alterations can be grouped into those that accumulate during pancreatic intraepithelial neoplasia (precursor lesions) and thus are present in all cells of the infiltrating carcinoma, and those that accumulate specifically within the infiltrating carcinoma during subclonal evolution, resulting in genetic heterogeneity. Despite this heterogeneity there are nonetheless commonly altered cellular functions, such as pathways controlling the cell cycle, DNA damage repair, intracellular signaling and development, which could provide for a variety of drug targets. This review aims to summarize current knowledge of the genetics and genomics of pancreatic cancer from its inception to metastatic colonization, and to provide examples of how this information can be translated into the clinical setting for therapeutic benefit and personalized medicine.
AB - Pancreatic cancer is a highly lethal tumor type for which there are few viable therapeutic options. It is also caused by the accumulation of mutations in a variety of genes. These genetic alterations can be grouped into those that accumulate during pancreatic intraepithelial neoplasia (precursor lesions) and thus are present in all cells of the infiltrating carcinoma, and those that accumulate specifically within the infiltrating carcinoma during subclonal evolution, resulting in genetic heterogeneity. Despite this heterogeneity there are nonetheless commonly altered cellular functions, such as pathways controlling the cell cycle, DNA damage repair, intracellular signaling and development, which could provide for a variety of drug targets. This review aims to summarize current knowledge of the genetics and genomics of pancreatic cancer from its inception to metastatic colonization, and to provide examples of how this information can be translated into the clinical setting for therapeutic benefit and personalized medicine.
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U2 - 10.1186/gm430
DO - 10.1186/gm430
M3 - Review article
C2 - 23673020
AN - SCOPUS:84875159380
SN - 1756-994X
VL - 5
JO - Genome Medicine
JF - Genome Medicine
IS - 3
M1 - 26
ER -