Pain, Nociceptive vs. Neuropathic

S. J. Panchal, V. Grami

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic pain has been categorized as: nociceptive (somatic vs. visceral) and neuropathic (central vs. peripheral). Nociceptive pain is due to activation and continuous signaling from peripheral nociceptors. Neuropathic pain is initiated or caused by a primary lesion of the somatosensory system, from peripheral or central sources. This categorization of nociceptive versus neuropathic pain led to specific treatments for each type. Over time, it was recognized clinically that these concepts often overlapped and coexist in many patients with longstanding conditions. This led to a category of mixed pain. Studies in the past decade have demonstrated analgesic efficacy for medications generally considered for neuropathic pain in surgical models, presumed to be primarily examples of nociceptive pain.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages749-752
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Adjuvants
  • Anticonvulsants
  • Antidepressants
  • Central pain
  • Neurolytic
  • Neuromodulation
  • Neuropathic
  • Nociceptive
  • Peripheral nerve stimulation
  • Peripheral pain
  • Somatic pain
  • Spinal cord stimulator
  • Visceral pain
  • Windup

ASJC Scopus subject areas

  • General Medicine

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