P63 and P73: Teammates or adversaries?

Edward Ratovitski, Barry Trink, David Sidransky

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations


The status and interrelationship of p53 family members are critical elements in tumor progression. An intriguing paper in this issue of Cancer Cell (Rocco et al., 2006) reveals a new twist in the interactions between p63 and p73 following DNA damage, underscoring a role for p73 in the proapoptotic regulation of Puma, Noxa, and Bcl-2 in head and neck squamous cell carcinomas (HNSCC). These data define a pathway in which ΔNp63α promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program, suggesting that p63 levels and p73 status may be key determinants of tumor response in patients with HNSCC.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalCancer cell
Issue number1
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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