Abstract
We have examined whether the effects of acute (2 ppm/3 h) and subacute (0.3 ppm/72 h) ozone (O3) exposures on airways are mutually predictive. Inbred C57BL/6J (susceptible) and C3H/HeJ (resistant) mice are differentially responsive to inflammation induced by the 2 exposures. Breeding experiments and cosegregation analysis indicated that 2 separate genes control inflammatory responses: Inf (acute), Inf-2 (subacute). The genetic model was also used to examine the effects of both exposures on the magnitude and pattern of breathing. Results imply that mechanisms that control susceptibility to the 2 exposures are not the same, and that one response is not necessarily predictive of the other.
Original language | English (US) |
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Pages (from-to) | 279-289 |
Number of pages | 11 |
Journal | Toxicology Letters |
Volume | 72 |
Issue number | 1-3 |
DOIs | |
State | Published - Jun 1994 |
Keywords
- Airways
- Bronchoalveolar lavage
- Control of breathing
- Cosegregation analysis
- Hypercapnia
- Inbred mice
ASJC Scopus subject areas
- Toxicology