Oxygenation and hematocrit dependence of transverse relaxation rates of blood at 3T

Jason M. Zhao, Chekesha S. Clingman, M. Johanna Närväinen, Risto A. Kauppinen, Peter C.M. Van Zijl

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Knowledge of the transverse relaxation rates R2 and R 2* of blood is relevant for quantitative assessment of functional MRI (fMRI) results, including calibration of blood oxygenation and measurement of tissue oxygen extraction fractions (OEFs). In a temperature controlled circulation system, these rates were measured for blood in vitro at 3T under conditions akin to the physiological state. Single spin echo (SE) and gradient echo (GRE) sequences were used to determine R2 and R 2, respectively. Both rates varied quadratically with deoxygenation, and changes in R2* were found to be due predominantly to changes in R2. These data were used to estimate intravascular blood oxygenation level dependent (BOLD) contributions during visual activation. Due to the large R2* in venous blood, intravascular SE BOLD signal changes were larger than GRE effects at echo times above 30 ms. When including extravascular effects to estimate the total BOLD effect, GRE BOLD dominated due to the large tissue volume fraction.

Original languageEnglish (US)
Pages (from-to)592-597
Number of pages6
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Sep 2007


  • BOLD
  • Blood
  • Extravascular
  • Intravascular
  • Oxygenation
  • Transverse relaxation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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