Oxygen sensing and homeostasis

Nanduri R. Prabhakar; Gregg L. Semenza

doi:10.1152/physiol.00022.2015

Oxygen sensing and homeostasis

Nanduri R. Prabhakar
, Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

Original language	English (US)
Pages (from-to)	340-348
Number of pages	9
Journal	Physiology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1152/physiol.00022.2015
State	Published - Sep 1 2015

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00022.2015

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title = "Oxygen sensing and homeostasis",

abstract = "The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.",

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AB - The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

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Oxygen sensing and homeostasis

Abstract

ASJC Scopus subject areas

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