Abstract
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
Original language | English (US) |
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Pages (from-to) | 340-348 |
Number of pages | 9 |
Journal | Physiology |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2015 |
ASJC Scopus subject areas
- Physiology