Oxygen consumption of human blood platelets. I. Effect of thrombin

Joseph Muenzer, Eugene C. Weinbach, Sidney M. Wolfe

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The effect of thrombin on the oxygen consumption of washed human platelets was measured polarographically with the Clark oxygen electrode. The average basal respiratory rate was 18±1.6 (mean ±S.E.) natoms oxygen per min per 109 platelets. Thrombin (1.9 units/ml) caused a 4-13-fold increase in the rate of oxygen consumption (138±14 (mean ±S.E.) natoms oxygen per min per 109 platelets). The thrombin-stimulated increase of oxygen consumption was transient, lasting from 1 to 1.5 min before returning to the respiratory rate observed before the thrombin addition. Release of platelet constituents appeared to precede the stimulation of oxygen consumption. These results may provide a basis for explaining the discrepancy in the literature concerning the effects of thrombin on platelet respiration.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalBBA - Bioenergetics
Issue number2
StatePublished - Feb 17 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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