Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Vera L. Bonilha; Mary E. Rayborn; Xiaoping Yang; Chengsong Xie; Huaibin Cai

doi:10.1007/978-1-4614-3209-8_81

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Vera L. Bonilha, Mary E. Rayborn, Xiaoping Yang, Chengsong Xie, Huaibin Cai

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.

Original language	English (US)
Pages (from-to)	649-654
Number of pages	6
Journal	Advances in experimental medicine and biology
Volume	801
DOIs	https://doi.org/10.1007/978-1-4614-3209-8_81
State	Published - 2014

Keywords

DJ-1
Histology
Oxidative stress
Reactive oxygen species
Retinal pigment epithelium

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-1-4614-3209-8_81

Cite this

@article{f38493d5131a4324b57bd9e2392542d7,

title = "Oxidative stress regulation by DJ-1 in the retinal pigment epithelium",

abstract = "DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson{\textquoteright}s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.",

keywords = "DJ-1, Histology, Oxidative stress, Reactive oxygen species, Retinal pigment epithelium",

author = "Bonilha, {Vera L.} and Rayborn, {Mary E.} and Xiaoping Yang and Chengsong Xie and Huaibin Cai",

note = "Funding Information: Supported by Research Center grants from the Foundation Fighting Blindness and Research to Prevent Blindness and funds from the Cleveland Clinic Foundation and partially by the intramural research program of National Institute on Aging (HC). Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media, LLC.",

year = "2014",

doi = "10.1007/978-1-4614-3209-8_81",

language = "English (US)",

volume = "801",

pages = "649--654",

journal = "Advances in experimental medicine and biology",

issn = "0065-2598",

publisher = "Springer New York",

}

TY - JOUR

T1 - Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

AU - Bonilha, Vera L.

AU - Rayborn, Mary E.

AU - Yang, Xiaoping

AU - Xie, Chengsong

AU - Cai, Huaibin

N1 - Funding Information: Supported by Research Center grants from the Foundation Fighting Blindness and Research to Prevent Blindness and funds from the Cleveland Clinic Foundation and partially by the intramural research program of National Institute on Aging (HC). Publisher Copyright: © 2014, Springer Science+Business Media, LLC.

PY - 2014

Y1 - 2014

N2 - DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.

AB - DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.

KW - DJ-1

KW - Histology

KW - Oxidative stress

KW - Reactive oxygen species

KW - Retinal pigment epithelium

UR - http://www.scopus.com/inward/record.url?scp=84904790236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904790236&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-3209-8_81

DO - 10.1007/978-1-4614-3209-8_81

M3 - Article

C2 - 24664754

AN - SCOPUS:84904790236

SN - 0065-2598

VL - 801

SP - 649

EP - 654

JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this