Overview of the pathway and functions of nitric oxide.

J. F. Dillman, V. L. Dawson, T. M. Dawson

Research output: Contribution to journalReview articlepeer-review


Nitric oxide has been recognized for years as a toxic, reactive, free radical gas, but in recent years it has been identified as having functions in a variety of metabolic and signaling pathways. NO is synthesized, by nitric oxide synthase, on demand and diffuses to the site of action where it forms noncovalent and covalent linkages with target molecules. This overview presents the pathway of NO formation and also discusses the functions of NO in the nervous, immune and vascular systems.

Original languageEnglish (US)
Pages (from-to)Unit 10.1
JournalCurrent protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]
VolumeChapter 10
StatePublished - May 2001
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology


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