@inbook{bc1a7dce951a4a568121f6bb6e5f4a9a,
title = "Overview of BCL-2 Family Proteins and Therapeutic Potentials",
abstract = "BCL-2 family proteins interact in a network that regulates apoptosis. The BH3 amino acid sequence motif serves to bind together this conglomerate protein family, both literally and figuratively. BH3 motifs are present in antiapoptotic and proapoptotic BCL-2 homologs, and in a separate group of unrelated BH3-only proteins often appended to the BCL-2 family. BH3-containing helices mediate many of their physical interactions to determine cell death versus survival, leading to the development of BH3 mimetics as therapeutics. Here we provide an overview of BCL-2 family interactions, their relevance in health and disease, and the progress toward regulating their interactions therapeutically.",
keywords = "Apoptosis, BAK, BAX, BCL-2, BCL-xL, BH3 mimetics, BH3-only, Navitoclax, Venetoclax",
author = "Huska, {Jason D.} and Lamb, {Heather M.} and Hardwick, {J. Marie}",
note = "Funding Information: Supported by the National Institutes of Health USA grants RO1 NS083373 (JMH), RO1 NS037402 (JMH), RO1 GM077875 (JMH), and F31 AI122613 (JDH). Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2019",
doi = "10.1007/978-1-4939-8861-7_1",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "1--21",
booktitle = "Methods in Molecular Biology",
}