Ovarian carcinogenesis: an alternative hypothesis.

Jurgen M J Piek, Paul J. van Diest, René H M Verheijen

Research output: Contribution to journalArticlepeer-review


Observations indicate three different tissues of origin for ovarian carcinoma. The ovarian surface epithelium, oviduct epithelium (TSE), and derivates of the Müllerian duct. This chapter discusses the TSE-related ovarian carcinogenesis (exfoliation theory). Recent evidence from prophylactic removed ovaries and Fallopian tubes shows (pre)neoplastic lesions primarily within the tubes and not in the ovaries, putting another light on the malignant potential of the tubal epithelium and possibly ovarian carcinogenesis.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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