TY - JOUR
T1 - Outwitting evolution
T2 - Fighting drug-resistant TB, Malaria, and HIV
AU - Goldberg, Daniel E.
AU - Siliciano, Robert F.
AU - Jacobs, William R.
N1 - Funding Information:
This work was supported by the Howard Hughes Medical Institute and by NIH grant AI081600 to R.F.S. Additional support came from the Einstein CFAR Grant NIH AI51519. Thanks to Brian Weinrick, Pradip Rathod, and Dhinakaran Samdbandan for their helpful discussions and suggestions.
PY - 2012/3/16
Y1 - 2012/3/16
N2 - Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learning how to manage and prevent resistance is a major medical challenge that requires an understanding of the evolutionary dynamics of each pathogen. This Review summarizes the similarities and differences in the evolution of drug resistance for these three pathogens.
AB - Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learning how to manage and prevent resistance is a major medical challenge that requires an understanding of the evolutionary dynamics of each pathogen. This Review summarizes the similarities and differences in the evolution of drug resistance for these three pathogens.
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U2 - 10.1016/j.cell.2012.02.021
DO - 10.1016/j.cell.2012.02.021
M3 - Review article
C2 - 22424234
AN - SCOPUS:84858389346
SN - 0092-8674
VL - 148
SP - 1271
EP - 1283
JO - Cell
JF - Cell
IS - 6
ER -