Outcomes of initial and repeat micro-pulse transscleral cyclophotocoagulation in adult glaucoma patients

Sara Hooshmand, Jackson Voss, Matthew Hirabayashi, Lindsey McDaniel, Jella An

Research output: Contribution to journalArticlepeer-review


Background: Micro-pulse transscleral cyclophotocoagulation (MP-TSCPC) has continued to gain popularity as a treatment in adult glaucoma patients. Thus far there is limited evidence reporting the efficaciousness and safety of retreatment. Objective: To evaluate safety and efficacy of primary and repeat MP-TSCPC procedures. Methods: Thirty-four of 67 eyes who failed to achieve target IOP from initial MP-TSCPC underwent repeat MP-TSCPC and followed for a minimum of 6 months. All treatments were performed using the laser power of 2000 or 2250 mW, duration of 100–200 s, and a velocity 16–20 s per hemisphere swipe. Success criteria were defined as intraocular pressure (IOP) reduction of greater than 20% from baseline or any medication reduction without additional glaucoma procedures at 6 months after repeat MP-TSCPC. The 6-month success rate after repeat MP-TSCPC was also compared to that of initial MP-TSCPC in the same group of eyes. Results: Mean baseline IOP before the repeat MP-TSCPC was 23.0 + /- 5.3 on 3.0 + /- 1.4 medications. At 6 months, mean post-op IOP was 18.2 + /- 5.4 (21.9% reduction, p < 0.002), with mean medication staying relatively the same (p =.976). Success rate was increased from 23.5% to 44.1% with the repeat procedure compared to that of initial procedure (p = 0.123). Mean IOP reduction was also greater after repeat MP-TSCPC (18.7%, p < 0.002) when compared to initial MP-TSCPC (10.4%). No adverse events occurred. Conclusions: MP-TSCPC is a safe and effective non-invasive means to lower IOP in a variety of glaucoma patients. While over 50% (34/67) of eyes required repeat MP-TSCPC, repeat treatment resulted in greater success rates and IOP reduction without any adverse events when using the total energy between 112 and 150 J.

Original languageEnglish (US)
JournalTherapeutic Advances in Ophthalmology
StatePublished - Jan 1 2022
Externally publishedYes


  • glaucoma
  • IOP
  • repeat MP-TSCPC

ASJC Scopus subject areas

  • Ophthalmology


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