Other hormonal therapies and men’s health

Dorota J. Hawksworth, Arthur L. Burnett

Research output: Chapter in Book/Report/Conference proceedingChapter


While exogenous testosterone therapy is a very effective treatment for male testosterone deficiency, it carries a significant risk of infertility. Other hormonal, nontestosterone formulations, such as luteinizing hormone agonists, selective estrogen receptor modulators, and aromatase inhibitors, are currently available as alternative therapeutic options. These substances all influence the hypothalamic-pituitary-gonadal axis at different levels of gonadotropin production and not only correct testosterone deficiency but also either preserve or restore fertility potential in affected men. In this chapter, the authors discuss these three classes of commonly used medications, their biochemical mechanisms, hormonal effects, as well as known risks and overall health benefits.

Original languageEnglish (US)
Title of host publicationEffects of Lifestyle on Men’s Health
Number of pages16
ISBN (Electronic)9780128166659
StatePublished - Jan 1 2019


  • Aromatase inhibitor
  • Estradiol
  • Human chorionic gonadotropin
  • Selective estrogen receptor modulator
  • Spermatogenesis
  • Testosterone deficiency
  • Testosterone therapy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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