Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Anneleen Remmerie; Liesbet Martens; Tinne Thoné; Angela Castoldi; Ruth Seurinck; Benjamin Pavie; Joris Roels; Bavo Vanneste; Sofie De Prijck; Mathias Vanhockerhout; Mushida Binte Abdul Latib; Lindsey Devisscher; Anne Hoorens; Johnny Bonnardel; Niels Vandamme; Anna Kremer; Peter Borghgraef; Hans Van Vlierberghe; Saskia Lippens; Edward Pearce; Yvan Saeys; Charlotte L. Scott

doi:10.1016/j.immuni.2020.08.004

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Anneleen Remmerie
, Liesbet Martens
, Tinne Thoné
, Angela Castoldi
, Ruth Seurinck
, Benjamin Pavie
, Joris Roels
, Bavo Vanneste
, Sofie De Prijck
, Mathias Vanhockerhout
, Mushida Binte Abdul Latib
, Lindsey Devisscher
, Anne Hoorens
, Johnny Bonnardel
, Niels Vandamme
, Anna Kremer
, Peter Borghgraef
, Hans Van Vlierberghe
, Saskia Lippens
, Edward Pearce

Yvan Saeys, Charlotte L. Scott

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatic macrophages are thought to play key roles in the pathogenesis of fatty liver disease; however, heterogeneity within the macrophage pool remains largely unstudied. In this issue of Immunity, Remmerie et al. report a population of osteopontin-expressing macrophages with a unique transcriptional profile and location in the fatty liver.

Original language	English (US)
Pages (from-to)	641-657.e14
Journal	Immunity
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2020.08.004
State	Published - Sep 15 2020
Externally published	Yes

Keywords

Kupffer cells
MAFLD
NAFLD
NASH
Western Diet
lipid
liver
macrophages
subsets

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2020.08.004

Cite this

Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., Binte Abdul Latib, M., Devisscher, L., Hoorens, A., Bonnardel, J., Vandamme, N., Kremer, A., Borghgraef, P., Van Vlierberghe, H., Lippens, S., ... Scott, C. L. (2020). Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver. Immunity, 53(3), 641-657.e14. https://doi.org/10.1016/j.immuni.2020.08.004

Remmerie, A, Martens, L, Thoné, T, Castoldi, A, Seurinck, R, Pavie, B, Roels, J, Vanneste, B, De Prijck, S, Vanhockerhout, M, Binte Abdul Latib, M, Devisscher, L, Hoorens, A, Bonnardel, J, Vandamme, N, Kremer, A, Borghgraef, P, Van Vlierberghe, H, Lippens, S, Pearce, E, Saeys, Y & Scott, CL 2020, 'Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver', Immunity, vol. 53, no. 3, pp. 641-657.e14. https://doi.org/10.1016/j.immuni.2020.08.004

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title = "Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver",

abstract = "Hepatic macrophages are thought to play key roles in the pathogenesis of fatty liver disease; however, heterogeneity within the macrophage pool remains largely unstudied. In this issue of Immunity, Remmerie et al. report a population of osteopontin-expressing macrophages with a unique transcriptional profile and location in the fatty liver.",

keywords = "Kupffer cells, MAFLD, NAFLD, NASH, Western Diet, lipid, liver, macrophages, subsets",

author = "Anneleen Remmerie and Liesbet Martens and Tinne Thon{\'e} and Angela Castoldi and Ruth Seurinck and Benjamin Pavie and Joris Roels and Bavo Vanneste and \{De Prijck\}, Sofie and Mathias Vanhockerhout and \{Binte Abdul Latib\}, Mushida and Lindsey Devisscher and Anne Hoorens and Johnny Bonnardel and Niels Vandamme and Anna Kremer and Peter Borghgraef and \{Van Vlierberghe\}, Hans and Saskia Lippens and Edward Pearce and Yvan Saeys and Scott, \{Charlotte L.\}",

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doi = "10.1016/j.immuni.2020.08.004",

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AU - Martens, Liesbet

AU - Thoné, Tinne

AU - Castoldi, Angela

AU - Seurinck, Ruth

AU - Pavie, Benjamin

AU - Roels, Joris

AU - Vanneste, Bavo

AU - De Prijck, Sofie

AU - Vanhockerhout, Mathias

AU - Binte Abdul Latib, Mushida

AU - Devisscher, Lindsey

AU - Hoorens, Anne

AU - Bonnardel, Johnny

AU - Vandamme, Niels

AU - Kremer, Anna

AU - Borghgraef, Peter

AU - Van Vlierberghe, Hans

AU - Lippens, Saskia

AU - Pearce, Edward

AU - Saeys, Yvan

AU - Scott, Charlotte L.

PY - 2020/9/15

Y1 - 2020/9/15

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AB - Hepatic macrophages are thought to play key roles in the pathogenesis of fatty liver disease; however, heterogeneity within the macrophage pool remains largely unstudied. In this issue of Immunity, Remmerie et al. report a population of osteopontin-expressing macrophages with a unique transcriptional profile and location in the fatty liver.

KW - Kupffer cells

KW - MAFLD

KW - NAFLD

KW - NASH

KW - Western Diet

KW - lipid

KW - liver

KW - macrophages

KW - subsets

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ER -

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Abstract

Keywords

ASJC Scopus subject areas

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