Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis

Jay R. Shapiro

Research output: Chapter in Book/Report/Conference proceedingChapter


Although osteoporosis is primarily considered an issue for postmenopausal women and men over age 65 years, physicians are increasingly confronted with low bone mass or fractures affecting a younger population. This is facilitated by three factors: (1) the increased awareness of osteoporosis as a cause of fractures in younger individuals, (2) the availability of bone density measurements, and (3) the availability of different treatment options for osteoporosis in younger individuals. Because osteoporosis is recognized with increasing frequency in young adults, the clinician is faced with a differential diagnosis that may include an inherited disorder such as osteogenesis imperfecta (OI) or acquired endocrine, gastrointestinal, and renal disorders. These include hyperparathyroidism, Cushing syndrome, occult malabsorption (e.g., celiac disease), and idiopathic hypercalcuria. Osteoporosis due to occult malignancy must also be considered in a young adult. A difficult therapeutic decision confronts the clinician when secondary causes of osteoporosis are excluded, and the remaining diagnosis is primary osteoporosis in a young adult.

Original languageEnglish (US)
Title of host publicationOsteoporosis
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Number of pages38
ISBN (Print)9780124158535
StatePublished - Jun 2013
Externally publishedYes


  • Bisphosphonate
  • Bone biomarkers
  • Bone mass
  • Bone turnover
  • Bruck syndrome
  • COL1A1 and COLIA2
  • Connective tissue
  • Dominant/negative mutations
  • Ehlers-Danlos syndrome (EDS)
  • Idiopathic juvenile osteoporosis (IJO)
  • Osteoporosis imperfecta (OI)
  • Type I collagen

ASJC Scopus subject areas

  • General Dentistry
  • General Medicine


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