Osteoblast menin regulates bone mass in vivo

Ippei Kanazawa; Lucie Canaff; Jad Abi Rafeh; Aarti Angrula; Jingjing Li; Ryan C. Riddle; Iris Boraschi-Diaz; Svetlana V. Komarova; Thomas L. Clemens; Monzur Murshed; Geoffrey N. Hendy

doi:10.1074/jbc.M114.629899

Osteoblast menin regulates bone mass in vivo

Ippei Kanazawa, Lucie Canaff, Jad Abi Rafeh, Aarti Angrula, Jingjing Li, Ryan C. Riddle, Iris Boraschi-Diaz, Svetlana V. Komarova, Thomas L. Clemens, Monzur Murshed, Geoffrey N. Hendy

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: Constitutive homozygous Men1^-/- mice at mid-gestation are small with craniofacial defects. Results: Conditional osteoblast Men1 knock-out mice have reduced bone mass, and transgenic osteoblast menin-overexpressing mice have increased bone mass. Conclusion: Knock-out mice menin-deficient primary osteoblasts have impaired mineralization and reduced responsiveness to TGF-β and BMP-2. Significance: Menin is a potential target for gain of function therapeutics in low bone mass disorders.

Original language	English (US)
Pages (from-to)	3910-3924
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.629899
State	Published - Feb 13 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M114.629899

Cite this

@article{52745e4e395242d1af3c320c7caaac3e,

title = "Osteoblast menin regulates bone mass in vivo",

abstract = "Background: Constitutive homozygous Men1-/- mice at mid-gestation are small with craniofacial defects. Results: Conditional osteoblast Men1 knock-out mice have reduced bone mass, and transgenic osteoblast menin-overexpressing mice have increased bone mass. Conclusion: Knock-out mice menin-deficient primary osteoblasts have impaired mineralization and reduced responsiveness to TGF-β and BMP-2. Significance: Menin is a potential target for gain of function therapeutics in low bone mass disorders.",

author = "Ippei Kanazawa and Lucie Canaff and Rafeh, {Jad Abi} and Aarti Angrula and Jingjing Li and Riddle, {Ryan C.} and Iris Boraschi-Diaz and Komarova, {Svetlana V.} and Clemens, {Thomas L.} and Monzur Murshed and Hendy, {Geoffrey N.}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.",

year = "2015",

month = feb,

day = "13",

doi = "10.1074/jbc.M114.629899",

language = "English (US)",

volume = "290",

pages = "3910--3924",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "7",

}

TY - JOUR

T1 - Osteoblast menin regulates bone mass in vivo

AU - Kanazawa, Ippei

AU - Canaff, Lucie

AU - Rafeh, Jad Abi

AU - Angrula, Aarti

AU - Li, Jingjing

AU - Riddle, Ryan C.

AU - Boraschi-Diaz, Iris

AU - Komarova, Svetlana V.

AU - Clemens, Thomas L.

AU - Murshed, Monzur

AU - Hendy, Geoffrey N.

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: Constitutive homozygous Men1-/- mice at mid-gestation are small with craniofacial defects. Results: Conditional osteoblast Men1 knock-out mice have reduced bone mass, and transgenic osteoblast menin-overexpressing mice have increased bone mass. Conclusion: Knock-out mice menin-deficient primary osteoblasts have impaired mineralization and reduced responsiveness to TGF-β and BMP-2. Significance: Menin is a potential target for gain of function therapeutics in low bone mass disorders.

AB - Background: Constitutive homozygous Men1-/- mice at mid-gestation are small with craniofacial defects. Results: Conditional osteoblast Men1 knock-out mice have reduced bone mass, and transgenic osteoblast menin-overexpressing mice have increased bone mass. Conclusion: Knock-out mice menin-deficient primary osteoblasts have impaired mineralization and reduced responsiveness to TGF-β and BMP-2. Significance: Menin is a potential target for gain of function therapeutics in low bone mass disorders.

UR - http://www.scopus.com/inward/record.url?scp=84922771783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922771783&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.629899

DO - 10.1074/jbc.M114.629899

M3 - Article

C2 - 25538250

AN - SCOPUS:84922771783

SN - 0021-9258

VL - 290

SP - 3910

EP - 3924

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Osteoblast menin regulates bone mass in vivo

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this