Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

Miguel Aller Pellitero; Nandini Kundu; Jonathan Sczepanski; Netzahualcóyotl Arroyo-Currás

doi:10.1039/d2an01901a

Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

Miguel Aller Pellitero, Nandini Kundu, Jonathan Sczepanski, Netzahualcóyotl Arroyo-Currás

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(ii/iii) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

Original language	English (US)
Pages (from-to)	806-813
Number of pages	8
Journal	Analyst
Volume	148
Issue number	4
DOIs	https://doi.org/10.1039/d2an01901a
State	Published - Jan 5 2023

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Spectroscopy
Electrochemistry
Environmental Chemistry

Access to Document

10.1039/d2an01901a

Cite this

@article{047a82741d814dada70896521faf1179,

title = "Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter",

abstract = "DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(ii/iii) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.",

author = "{Aller Pellitero}, Miguel and Nandini Kundu and Jonathan Sczepanski and Netzahualc{\'o}yotl Arroyo-Curr{\'a}s",

note = "Funding Information: This study was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM140143. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = jan,

day = "5",

doi = "10.1039/d2an01901a",

language = "English (US)",

volume = "148",

pages = "806--813",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

AU - Aller Pellitero, Miguel

AU - Kundu, Nandini

AU - Sczepanski, Jonathan

AU - Arroyo-Currás, Netzahualcóyotl

N1 - Funding Information: This study was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM140143. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2023 The Royal Society of Chemistry.

PY - 2023/1/5

Y1 - 2023/1/5

N2 - DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(ii/iii) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

AB - DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(ii/iii) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

UR - http://www.scopus.com/inward/record.url?scp=85146223951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85146223951&partnerID=8YFLogxK

U2 - 10.1039/d2an01901a

DO - 10.1039/d2an01901a

M3 - Article

C2 - 36632808

AN - SCOPUS:85146223951

SN - 0003-2654

VL - 148

SP - 806

EP - 813

JO - Analyst

JF - Analyst

IS - 4

ER -

Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this