Orthostatic Intolerance and Chiari I Malformation

Lindsay S. Petracek; Peter C. Rowe

doi:10.1016/j.nec.2022.09.002

Orthostatic Intolerance and Chiari I Malformation

Lindsay S. Petracek, Peter C. Rowe

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control centers and their pathways in the brainstem. This article reviews the normal physiologic response to upright posture and the common forms of orthostatic intolerance encountered in clinical practice. The authors describe the relationship between orthostatic intolerance and Chiari malformation and provide suggestions regarding the evaluation and management of these disorders.

Original language	English (US)
Pages (from-to)	43-54
Number of pages	12
Journal	Neurosurgery clinics of North America
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.nec.2022.09.002
State	Published - Jan 2023

Keywords

Cervical spinal stenosis
Chiari malformation
Craniocervical instability
Joint hypermobility
Neurally mediated hypotension
Orthostatic intolerance
Postural tachycardia syndrome
Syncope

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.nec.2022.09.002

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title = "Orthostatic Intolerance and Chiari I Malformation",

abstract = "Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control centers and their pathways in the brainstem. This article reviews the normal physiologic response to upright posture and the common forms of orthostatic intolerance encountered in clinical practice. The authors describe the relationship between orthostatic intolerance and Chiari malformation and provide suggestions regarding the evaluation and management of these disorders.",

keywords = "Cervical spinal stenosis, Chiari malformation, Craniocervical instability, Joint hypermobility, Neurally mediated hypotension, Orthostatic intolerance, Postural tachycardia syndrome, Syncope",

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AU - Rowe, Peter C.

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N2 - Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control centers and their pathways in the brainstem. This article reviews the normal physiologic response to upright posture and the common forms of orthostatic intolerance encountered in clinical practice. The authors describe the relationship between orthostatic intolerance and Chiari malformation and provide suggestions regarding the evaluation and management of these disorders.

AB - Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control centers and their pathways in the brainstem. This article reviews the normal physiologic response to upright posture and the common forms of orthostatic intolerance encountered in clinical practice. The authors describe the relationship between orthostatic intolerance and Chiari malformation and provide suggestions regarding the evaluation and management of these disorders.

KW - Cervical spinal stenosis

KW - Chiari malformation

KW - Craniocervical instability

KW - Joint hypermobility

KW - Neurally mediated hypotension

KW - Orthostatic intolerance

KW - Postural tachycardia syndrome

KW - Syncope

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JO - Neurosurgery clinics of North America

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Orthostatic Intolerance and Chiari I Malformation

Abstract

Keywords

ASJC Scopus subject areas

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