Orthostatic and non-orthostatic headache in postural tachycardia syndrome

Ramesh K. Khurana, Lindsay Eisenberg

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Objective: Orthostatic and non-orthostatic headache spectrum was prospectively studied in 24 consecutive patients with postural orthostatic tachycardia syndrome (POTS). Methods: Patients were interviewed about clinical aspects of headache and its precipitation during head-up tilt (HUT). Autonomic functions were assessed using a standard battery of tests. The relationship of orthostatic headache to cardiovascular variables was examined using unpaired two-tailed t-test. Results: Orthostatic headache occurred during daily activity in 14 patients (58.3%) and during HUT in 15 patients (62.5%). Age under 30 years and increasing duration of tilt were predictive for orthostatic headache. Of the 24 patients, 23 (95.8%) had non-orthostatic headache fitting the criteria of migraine or probable migraine. Conclusions: Orthostatic headache affected two-thirds of POTS patients, especially those under age 30. Patients with orthostatic headache should be clinically assessed for POTS and informed of this association to reduce short-term morbidity. Migraine afflicted almost all POTS patients. This co-morbidity should be considered in management of POTS.

Original languageEnglish (US)
Pages (from-to)409-415
Number of pages7
Issue number4
StatePublished - Apr 1 2011
Externally publishedYes


  • Postural tachycardia syndrome
  • migraine
  • orthostatic headache

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Orthostatic and non-orthostatic headache in postural tachycardia syndrome'. Together they form a unique fingerprint.

Cite this