Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Caroline C. Traut; Joyce L. Jones; Renata A. Sanders; Laura R. Clark; Matthew M. Hamill; Georgia Stavrakis; Joel Sop; Tyler P. Beckey; Sara C. Keller; Elizabeth A. Gilliams; Willa V. Cochran; Oliver Laeyendecker; Yukari C. Manabe; Heba H. Mostafa; David L. Thomas; Bhakti Hansoti; Kelly A. Gebo; Joel N. Blankson

doi:10.1093/infdis/jiad245

Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Caroline C. Traut, Joyce L. Jones, Renata A. Sanders, Laura R. Clark, Matthew M. Hamill, Georgia Stavrakis, Joel Sop, Tyler P. Beckey, Sara C. Keller, Elizabeth A. Gilliams, Willa V. Cochran, Oliver Laeyendecker, Yukari C. Manabe, Heba H. Mostafa, David L. Thomas, Bhakti Hansoti, Kelly A. Gebo, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4⁺ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2-positive participants targeted at least 1 previously described HLA-A2-restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients.

Original language	English (US)
Pages (from-to)	54-58
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	229
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiad245
State	Published - Jan 15 2024

Keywords

Mpox
PWH
T-cells
orthopoxvirus

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiad245

Cite this

Traut, C. C., Jones, J. L., Sanders, R. A., Clark, L. R., Hamill, M. M., Stavrakis, G., Sop, J., Beckey, T. P., Keller, S. C., Gilliams, E. A., Cochran, W. V., Laeyendecker, O., Manabe, Y. C., Mostafa, H. H., Thomas, D. L., Hansoti, B., Gebo, K. A., & Blankson, J. N. (2024). Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients. Journal of Infectious Diseases, 229(1), 54-58. https://doi.org/10.1093/infdis/jiad245

Traut, CC, Jones, JL, Sanders, RA, Clark, LR, Hamill, MM, Stavrakis, G, Sop, J, Beckey, TP, Keller, SC , Gilliams, EA, Cochran, WV, Laeyendecker, O, Manabe, YC , Mostafa, HH , Thomas, DL , Hansoti, B , Gebo, KA & Blankson, JN 2024, 'Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients', Journal of Infectious Diseases, vol. 229, no. 1, pp. 54-58. https://doi.org/10.1093/infdis/jiad245

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title = "Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients",

abstract = "Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2-positive participants targeted at least 1 previously described HLA-A2-restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients.",

keywords = "Mpox, PWH, T-cells, orthopoxvirus",

author = "Traut, {Caroline C.} and Jones, {Joyce L.} and Sanders, {Renata A.} and Clark, {Laura R.} and Hamill, {Matthew M.} and Georgia Stavrakis and Joel Sop and Beckey, {Tyler P.} and Keller, {Sara C.} and Gilliams, {Elizabeth A.} and Cochran, {Willa V.} and Oliver Laeyendecker and Manabe, {Yukari C.} and Mostafa, {Heba H.} and Thomas, {David L.} and Bhakti Hansoti and Gebo, {Kelly A.} and Blankson, {Joel N.}",

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AU - Hamill, Matthew M.

AU - Stavrakis, Georgia

AU - Sop, Joel

AU - Beckey, Tyler P.

AU - Keller, Sara C.

AU - Gilliams, Elizabeth A.

AU - Cochran, Willa V.

AU - Laeyendecker, Oliver

AU - Manabe, Yukari C.

AU - Mostafa, Heba H.

AU - Thomas, David L.

AU - Hansoti, Bhakti

AU - Gebo, Kelly A.

AU - Blankson, Joel N.

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AB - Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2-positive participants targeted at least 1 previously described HLA-A2-restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients.

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Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Abstract

Keywords

ASJC Scopus subject areas

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