Orthopaedic Manifestations of Inborn Errors of Metabolism

Niyathi Prasad, Ada Hamosh, Paul Sponseller

Research output: Contribution to journalReview articlepeer-review


Inborn errors of metabolism are disorders of carbohydrate, amino acid, organic acid, or purine and pyrimidine metabolism; disorders of fatty acid oxidation; disorders of metal metabolism; and lysosomal storage defects that can cause metabolic derangements that have secondary musculoskeletal effects.Orthopaedic surgeons should be aware that patients with inborn errors of metabolism may be at high risk for spasticity, which may cause joint subluxations, scoliosis, and contractures, as well as poor bone quality, which is caused by malnutrition or disordered bone growth.Multidisciplinary care and follow-up are important to identify musculoskeletal problems in a timely manner in order to provide effective treatment.

Original languageEnglish (US)
Article number20.00245
JournalJBJS reviews
Issue number7
StatePublished - Jul 14 2021

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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