Organometallic carbonyl clusters: A new class of contrast agents for photoacoustic cerebral vascular imaging

Kien Voon Kong; Lun De Liao; Zhiyong Lam; Nitish V. Thakor; Weng Kee Leong; Malini Olivo

doi:10.1039/c3cc48529c

Organometallic carbonyl clusters: A new class of contrast agents for photoacoustic cerebral vascular imaging

Kien Voon Kong, Lun De Liao, Zhiyong Lam, Nitish V. Thakor, Weng Kee Leong, Malini Olivo

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.

Original language	English (US)
Pages (from-to)	2601-2603
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	20
DOIs	https://doi.org/10.1039/c3cc48529c
State	Published - Feb 11 2014

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.",

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AU - Kong, Kien Voon

AU - Liao, Lun De

AU - Lam, Zhiyong

AU - Thakor, Nitish V.

AU - Leong, Weng Kee

AU - Olivo, Malini

PY - 2014/2/11

Y1 - 2014/2/11

N2 - We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.

AB - We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.

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Organometallic carbonyl clusters: A new class of contrast agents for photoacoustic cerebral vascular imaging

Abstract

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