TY - JOUR
T1 - Orbital and central nervous system extension of nasal natural killer/T-cell lymphoma
AU - Cruz, Antonio A.V.
AU - Valera, Fabiana C.P.
AU - Carenzi, Lucas
AU - Chahud, Fernando
AU - Barros, Gyl E.
AU - Elias, Jorge
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND: To describe a case series of nasal natural killer (NK)/T-cell lymphoma (NKTL) with orbital and central nervous system extension. METHODS: This is a retrospective study. The medical records of 9 patients with a diagnosis of NKTL were reviewed. All patients had a positive biopsy for CD3, CD56, T-cell-restricted intracellular antigen-1, and granzyme expression and CT imaging of nose, sinuses, orbits, and brain. Five patients were also examined with MRI. RESULTS: Orbital extension occurred in 6 patients. All had extraocular muscle enlargement and 5 showed signs of perineural spread. CONCLUSIONS: NKTL is a polymorphous disease. Extraocular muscle involvement and perineural spread are overlooked features that explain dissemination of the tumor to both the orbit and the central nervous system.
AB - BACKGROUND: To describe a case series of nasal natural killer (NK)/T-cell lymphoma (NKTL) with orbital and central nervous system extension. METHODS: This is a retrospective study. The medical records of 9 patients with a diagnosis of NKTL were reviewed. All patients had a positive biopsy for CD3, CD56, T-cell-restricted intracellular antigen-1, and granzyme expression and CT imaging of nose, sinuses, orbits, and brain. Five patients were also examined with MRI. RESULTS: Orbital extension occurred in 6 patients. All had extraocular muscle enlargement and 5 showed signs of perineural spread. CONCLUSIONS: NKTL is a polymorphous disease. Extraocular muscle involvement and perineural spread are overlooked features that explain dissemination of the tumor to both the orbit and the central nervous system.
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U2 - 10.1097/IOP.0b013e3182a7500e
DO - 10.1097/IOP.0b013e3182a7500e
M3 - Article
C2 - 24398482
AN - SCOPUS:84893075456
SN - 0740-9303
VL - 30
SP - 20
EP - 23
JO - Ophthalmic plastic and reconstructive surgery
JF - Ophthalmic plastic and reconstructive surgery
IS - 1
ER -