Orbital and central nervous system extension of nasal natural killer/T-cell lymphoma

Antonio A.V. Cruz, Fabiana C.P. Valera, Lucas Carenzi, Fernando Chahud, Gyl E. Barros, Jorge Elias

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


BACKGROUND: To describe a case series of nasal natural killer (NK)/T-cell lymphoma (NKTL) with orbital and central nervous system extension. METHODS: This is a retrospective study. The medical records of 9 patients with a diagnosis of NKTL were reviewed. All patients had a positive biopsy for CD3, CD56, T-cell-restricted intracellular antigen-1, and granzyme expression and CT imaging of nose, sinuses, orbits, and brain. Five patients were also examined with MRI. RESULTS: Orbital extension occurred in 6 patients. All had extraocular muscle enlargement and 5 showed signs of perineural spread. CONCLUSIONS: NKTL is a polymorphous disease. Extraocular muscle involvement and perineural spread are overlooked features that explain dissemination of the tumor to both the orbit and the central nervous system.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalOphthalmic plastic and reconstructive surgery
Issue number1
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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