Orally administered MDMA causes a long-term depletion of serotonin in rat brain

K. T. Finnegan; G. A. Ricaurte; L. D. Ritchie; I. Irwin; S. J. Peroutka; J. W. Langston

doi:10.1016/0006-8993(88)90974-2

Orally administered MDMA causes a long-term depletion of serotonin in rat brain

K. T. Finnegan, G. A. Ricaurte, L. D. Ritchie, I. Irwin, S. J. Peroutka, J. W. Langston

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when administered subcutaneously, is toxic to central serotonergic neurons in rats. Because humans typically self-administer this drug orally, we compared this route to the s.c. route of administration. Orally administered MDMA produced a dose-related depletion of serotonin comparable to that produced by the s.c. route. These findings suggest that MDMA, when given orally, retains its neurotoxic activity and that humans using MDMA may be at risk for developing a persistent depletion of brain serotonin.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Brain research
Volume	447
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90974-2
State	Published - Apr 26 1988

Keywords

3,4-Methylenedioxymethylamphetamine
Amphetamine analog
Neurotoxicity
Route of administration
Serotonin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)90974-2

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title = "Orally administered MDMA causes a long-term depletion of serotonin in rat brain",

abstract = "Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when administered subcutaneously, is toxic to central serotonergic neurons in rats. Because humans typically self-administer this drug orally, we compared this route to the s.c. route of administration. Orally administered MDMA produced a dose-related depletion of serotonin comparable to that produced by the s.c. route. These findings suggest that MDMA, when given orally, retains its neurotoxic activity and that humans using MDMA may be at risk for developing a persistent depletion of brain serotonin.",

keywords = "3,4-Methylenedioxymethylamphetamine, Amphetamine analog, Neurotoxicity, Route of administration, Serotonin",

author = "Finnegan, {K. T.} and Ricaurte, {G. A.} and Ritchie, {L. D.} and I. Irwin and Peroutka, {S. J.} and Langston, {J. W.}",

note = "Funding Information: Supported in part by CPHF subcontract No. 091A-701 to J.W. Langston, and NS 23560-01 to S.J, Per-outka. The authors wish to acknowledge gratefully the assistance of ZoAnn McBride and David Rosner in the preparation of this manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Finnegan, K. T.

AU - Ricaurte, G. A.

AU - Ritchie, L. D.

AU - Irwin, I.

AU - Peroutka, S. J.

AU - Langston, J. W.

N1 - Funding Information: Supported in part by CPHF subcontract No. 091A-701 to J.W. Langston, and NS 23560-01 to S.J, Per-outka. The authors wish to acknowledge gratefully the assistance of ZoAnn McBride and David Rosner in the preparation of this manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1988/4/26

Y1 - 1988/4/26

N2 - Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when administered subcutaneously, is toxic to central serotonergic neurons in rats. Because humans typically self-administer this drug orally, we compared this route to the s.c. route of administration. Orally administered MDMA produced a dose-related depletion of serotonin comparable to that produced by the s.c. route. These findings suggest that MDMA, when given orally, retains its neurotoxic activity and that humans using MDMA may be at risk for developing a persistent depletion of brain serotonin.

AB - Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when administered subcutaneously, is toxic to central serotonergic neurons in rats. Because humans typically self-administer this drug orally, we compared this route to the s.c. route of administration. Orally administered MDMA produced a dose-related depletion of serotonin comparable to that produced by the s.c. route. These findings suggest that MDMA, when given orally, retains its neurotoxic activity and that humans using MDMA may be at risk for developing a persistent depletion of brain serotonin.

KW - 3,4-Methylenedioxymethylamphetamine

KW - Amphetamine analog

KW - Neurotoxicity

KW - Route of administration

KW - Serotonin

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Orally administered MDMA causes a long-term depletion of serotonin in rat brain

Abstract

Keywords

ASJC Scopus subject areas

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