Oral rehydration for diarrhea

Laurence Finberg, Paul A. Harper, Harold E. Harrison, R. Bradley Sack

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


To evaluate the effect of maternal dietary vitamin D intake on infant vitamin D status in a country with a temperate climate, but where the commercial milk supply is not vitamin D fortified, this randomized, double-blind study was conducted on term mother-infant pairs during the winter months. Well-nourished, white nursing mothers were given a placebo, 500 IU vitamin D/day or 1,000 IU vitamin D/day; their infants were not given supplemental vitamin D. After six weeks, mothers receiving supplemental vitamin D had higher levels of 25-hydroxyvitamin D than had mothers receiving placebo. A direct relationship was observed between maternal and infant levels of 25-hydroxyvitamin D at six weeks, implying that maternal vitamin D intake directly affects the vitamin D concentration in breast milk. A control group of infants who had received 400 IU vitamin D/day had even higher concentrations of 25-hydroxyvitamin D, suggesting that infant supplementation with vitamin D is more efficacious than maternal supplementation. Despite the favorable climate in South Africa, during winter breast-fed infants have low serum vitamin D values if maternal dietary vitamin D intake is low.

Original languageEnglish (US)
Pages (from-to)497-499
Number of pages3
JournalThe Journal of pediatrics
Issue number4
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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