Oral Multimodal Analgesia for Total Joint Arthroplasty

Gregory J. Golladay, Karl R. Balch, David F. Dalury, Jibanananda Satpathy, William A. Jiranek

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background Oral multimodal analgesia for hip and knee arthroplasty is increasingly used as part of enhanced recovery protocols designed to minimize early postoperative pain and to facilitate early discharge, while minimizing undesirable side effects related to single-agent opioid administration. Methods This article is a review of previously published data evaluating the use of various oral medications in the management of postoperative pain after lower extremity arthroplasty and was presented as part of a symposium at the November 2016 AAHKS Annual Meeting. Results Multimodal analgesia has been shown to reduce opioid consumption and side effects, with a positive effect on both early and longer term outcomes for hip and knee arthroplasty patients. Medications directed at multiple points on the pain cascade minimize pain by different mechanisms. Suggested dosing regimens are proposed. Conclusion Oral multimodal analgesia incorporating a combination of opioid and nonopioid analgesics, selective and nonselective anti-inflammatory drugs, acetaminophen, and gabapentinoids are recommended as a part of a pre-emptive approach to pain management in patients undergoing hip or knee arthroplasty. Reduction of opioid consumption and minimization of side effects are primary outcomes, and prevention of chronic pain can positively affect long-term results.

Original languageEnglish (US)
Pages (from-to)S69-S73
JournalJournal of Arthroplasty
Issue number9
StatePublished - Sep 2017
Externally publishedYes


  • analgesia
  • arthroplasty
  • multimodal
  • opioids
  • pain

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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