TY - JOUR
T1 - Oral health and later coronary heart disease
T2 - Cohort study of one million people
AU - Batty, G. David
AU - Jung, Keum Ji
AU - Mok, Yejin
AU - Lee, Sun Ju
AU - Back, Joung Hwan
AU - Lee, Sunmi
AU - Jee, Sun Ha
N1 - Publisher Copyright:
© The European Society of Cardiology 2018.
PY - 2018/4
Y1 - 2018/4
N2 - Aims: Systematic reviews report an association between poorer oral health and an increased risk of coronary heart disease. This contentious relationship may not be causal but existing studies have been insufficiently well powered comprehensively to examine the role of confounding, particularly by cigarette smoking. Accordingly, we sought to examine the role of smoking in generating the relationship between oral health and coronary heart disease in life-long non-smokers. Methods and results: In the Korean Cancer Prevention Study, 975,685 individuals (349,579 women) aged 30–95 years had an oral examination when tooth loss, a widely used indicator of oral health, was ascertained. Linkage to national mortality and hospital registers over 21 years of follow-up gave rise to 64,784 coronary heart disease events (19,502 in women). In the whole cohort, after statistical adjustment for age, there was a moderate, positive association between tooth loss and coronary heart disease in both men (hazard ratio for seven or more missing teeth vs. none; 95% confidence interval 1.08; 1.02, 1.14; Ptrendacross tooth loss groups <0.0001) and women (1.09; 1.01, 1.18; Ptrend0.0016). Restricting analyses to a subgroup of 464,145 never smokers (25,765 coronary heart disease events), however, resulted in an elimination of this association in men (1.01; 0.85, 1.19); Ptrend0.7506) but not women (1.08; 0.99, 1.18; Ptrend0.0086). Conclusion: In men in the present study, the relationship between poor oral health and coronary heart disease risk appeared to be explained by confounding by cigarette smoking so raising questions about a causal link.
AB - Aims: Systematic reviews report an association between poorer oral health and an increased risk of coronary heart disease. This contentious relationship may not be causal but existing studies have been insufficiently well powered comprehensively to examine the role of confounding, particularly by cigarette smoking. Accordingly, we sought to examine the role of smoking in generating the relationship between oral health and coronary heart disease in life-long non-smokers. Methods and results: In the Korean Cancer Prevention Study, 975,685 individuals (349,579 women) aged 30–95 years had an oral examination when tooth loss, a widely used indicator of oral health, was ascertained. Linkage to national mortality and hospital registers over 21 years of follow-up gave rise to 64,784 coronary heart disease events (19,502 in women). In the whole cohort, after statistical adjustment for age, there was a moderate, positive association between tooth loss and coronary heart disease in both men (hazard ratio for seven or more missing teeth vs. none; 95% confidence interval 1.08; 1.02, 1.14; Ptrendacross tooth loss groups <0.0001) and women (1.09; 1.01, 1.18; Ptrend0.0016). Restricting analyses to a subgroup of 464,145 never smokers (25,765 coronary heart disease events), however, resulted in an elimination of this association in men (1.01; 0.85, 1.19); Ptrend0.7506) but not women (1.08; 0.99, 1.18; Ptrend0.0086). Conclusion: In men in the present study, the relationship between poor oral health and coronary heart disease risk appeared to be explained by confounding by cigarette smoking so raising questions about a causal link.
KW - Coronary heart disease
KW - Epidemiology
KW - Oral health
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U2 - 10.1177/2047487318759112
DO - 10.1177/2047487318759112
M3 - Article
C2 - 29461088
AN - SCOPUS:85053431534
SN - 2047-4873
VL - 25
SP - 598
EP - 605
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 6
ER -