Oral eosinophilic granulomas in tigers (Panthera tigris)-a collection of 16 cases

John M. Sykes IV, Michael M. Garner, Leah L. Greer, Nancy P. Lung, Rob L. Coke, Frank Ridgley, Mitch Bush, Richard J. Montali, Ben Okimoto, Robert Schmidt, Jack L. Alien, Bruce A. Rideout, Patricia A. Pesavento, Edward C. Ramsay

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Oral eosinophilic granulomas were diagnosed in 16 tigers (Panthern tigris). All lesions were located on the hard or soft palate and typically consisted of flat or slightly raised circular ulcers. Histologie features of these lesions were essentially identical to those seen in oral eosinophilic granulomas of domestic cats and dogs. No clinical signs were noted in eight cases, though various degrees of inappetence, excessive salivation, and dysphagia were noted in the other eight tigers. Six cases were not treated. Treatment for the remaining 10 cases centered on corticosteroids and additional treatments included surgical removal, cryotherapy, antibiotics, and chlorpheniramine. Treatment with corticosteroids did appear to be effective in some cases, though lesions would worsen after cessation of therapy and no cases were cured. In addition, three cases developed complications possibly related to this corticosteroid therapy. The etiology of these lesions remains unknown, though an underlying allergic condition is likely.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalJournal of Zoo and Wildlife Medicine
Issue number2
StatePublished - Jun 2007
Externally publishedYes


  • Allergy
  • Eosinophilic granuloma
  • Panthera tigris
  • Tiger

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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