@article{2816e43524534780a1b536c62d8696ae,
title = "Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial",
abstract = "Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.",
keywords = "Cognitive decline, Cohort study, Dementia, Oral disease",
author = "Batty, {G. D.} and Q. Li and R. Huxley and S. Zoungas and Taylor, {B. A.} and B. Neal and {de Galan}, B. and M. Woodward and Harrap, {S. B.} and S. Colagiuri and A. Patel and J. Chalmers",
note = "Funding Information: The ADVANCE trial was funded by grants from Servier and the National Health and Medical Research Council of Australia. These sponsors had no role in the design of the study, data collection, data analysis, data interpretation, and the writing of the manuscript. Study data were not made available to the sponsors. The Management Committee, whose membership did not include any sponsor representatives, had final responsibility for the decision to submit this manuscript for publication. The authors had full access to the study data and take responsibility for the accuracy of the analysis. David Batty is a welcome trust career development fellow. The Medical Research Council (MRC) Social and Public Health Sciences Unit receives funding from the UK MRC and the Chief Scientist Office at the Scottish Government Health Directorates. The Centre for Cognitive Ageing and Cognitive Epidemiology is supported by the Biotechnology and Biological Sciences Research Council, the Engineering and Physical Sciences Research Council, the Economic and Social Research Council, the Medical Research Council, and the University of Edinburgh as part of the cross-council lifelong health and well-being initiative.",
year = "2013",
month = jan,
doi = "10.1016/j.eurpsy.2011.07.005",
language = "English (US)",
volume = "28",
pages = "49--52",
journal = "European Psychiatry",
issn = "0924-9338",
publisher = "Elsevier Masson",
number = "1",
}