Oral and maxillofacial manifestations of familial adenomatous polyposis

M. A. Wijn, J. J. Keller, F. M. Giardiello, H. S. Brand

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Patients with familial adenomatous polyposis (FAP) develop multiple premalignant colorectal adenomas. Untreated, one or more of these polyps will progress to colorectal carcinoma in middle-aged adults. Extra-intestinal manifestations of FAP are frequently observed and this combination has been called Gardner's syndrome. Oral and maxillofacial symptoms of FAP include an increased risk of jaw osteomas, odontomas and supernumerary or unerupted teeth. Early diagnosis of FAP is crucial and may be life saving. As oral signs usually precede gastrointestinal symptoms, the dentist may play an important role in the diagnosis of FAP.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalOral Diseases
Issue number4
StatePublished - Jul 2007
Externally publishedYes


  • APC-gene
  • Colorectal carcinoma
  • Gardner's syndrome
  • Odontoma
  • Osteoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • General Dentistry


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