Optimization of sample transfer in two-dimensional microfluidic separation systems

Shuang Yang, Jikun Liu, Don L. DeVoe

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Multidimensional microfluidic separation systems combining a first dimension microchannel with an array of parallel second dimension microchannels can suffer from non-uniform sample transfer between the dimensions, sample leakage, and injection plug tailing within the second dimension array. These factors can significantly reduce overall two-dimensional separation performance. In this paper, numerical and analytical models reveal an optimized chip design which combines multidimensional backbiasing and an angled channel geometry to ensure leakage-free and uniform interdimensional sample transfer, while also minimizing injected sample plug lengths. The optimized design is validated experimentally using a multidimensional chip containing five second dimension channels.

Original languageEnglish (US)
Pages (from-to)1145-1152
Number of pages8
JournalLab on a Chip
Issue number7
StatePublished - 2008

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering


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