Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals

Eduardo A. Gonzalez; Camryn A. Graham; Muyinatu A. Lediju Bell

doi:10.1117/12.2607825

Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals

Eduardo A. Gonzalez
, Camryn A. Graham
, Muyinatu A. Lediju Bell

Whiting School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Our dual wavelength atlas approach to spectral unmixing has the potential to differentiate two chromophores using only two optical wavelengths. This work investigates the optimization of our method by varying six parameters. An iterative process was used to determine the optimal set of parameters by changing each parameter one at a time and finding which value returned the highest combination of sensitivity and specificity. Once the optimal set of parameters were applied, our novel dual-wavelength atlas method resulted in 10% higher balanced accuracy. These results are promising for photoacoustic-guided surgery.

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2022
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510647916
DOIs	https://doi.org/10.1117/12.2607825
State	Published - 2022
Event	Photons Plus Ultrasound: Imaging and Sensing 2022 - Virtual, Online Duration: Feb 20 2022 → Feb 24 2022

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11960
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2022
City	Virtual, Online
Period	2/20/22 → 2/24/22

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2607825

Cite this

Gonzalez, E. A., Graham, C. A., & Lediju Bell, M. A. (2022). Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2022 Article 119600A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11960). SPIE. https://doi.org/10.1117/12.2607825

Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals. / Gonzalez, Eduardo A.; Graham, Camryn A.; Lediju Bell, Muyinatu A.
Photons Plus Ultrasound: Imaging and Sensing 2022. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2022. 119600A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11960).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gonzalez, EA, Graham, CA & Lediju Bell, MA 2022, Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2607825

Gonzalez, Eduardo A. ; Graham, Camryn A. ; Lediju Bell, Muyinatu A. / Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals. Photons Plus Ultrasound: Imaging and Sensing 2022. editor / Alexander A. Oraevsky ; Lihong V. Wang. SPIE, 2022. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals

Abstract

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