TY - JOUR
T1 - Optimism is associated with chronic kidney disease and rapid kidney function decline among African Americans in the Jackson Heart Study
AU - Glover, LáShauntá M.
AU - Butler-Williams, Crystal
AU - Cain-Shields, Loretta
AU - Forde, Allana T.
AU - Purnell, Tanjala S.
AU - Young, Bessie
AU - Sims, Mario
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - Objective: Investigate the association of dispositional optimism with chronic kidney disease (CKD) and rapid kidney function decline (RKFD) and determine if there is modification by age, sex, and educational attainment among African Americans. Methods: Optimism was measured using the 6-item Life Orientation Test-Revised scale (categorized into tertiles and log transformed) among participants from the Jackson Heart Study (n = 1960). CKD was defined as the presence of albuminuria or reduced glomerular filtration rate of <60 mL/min/1.73m2, or report of dialysis at baseline examination (2000–2004). RKFD was defined as a decline >3 mL/min/1.73m2/year between baseline and exam 3 (2009–2013). The cross-sectional and prospective associations between optimism and kidney outcomes were tested using multivariable logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI), adjusting for demographics, education, risk factors, behaviors, and depressive symptoms. We tested effect modification by age, sex, and education. Results: 569 participants had CKD and 326 were classified as having RKFD by exam 3. After full adjustment, the OR for CKD was 0.73 for those who reported high (vs. low) optimism (95% CI 0.55–0.99) and 0.56 (95% CI 0.27–1.15) for the optimism score. After 7.21 median years of follow up, the OR for RKFD was 0.51 for those who reported high (vs. low) optimism (95% CI 0.34–0.76), and 0.26 (95% CI 0.10–0.56) for the optimism score, after full adjustment. There was no evidence of effect modification by demographics or educational attainment. Conclusions: Higher optimism was associated with a lower odds of CKD and a lower odds of RKFD.
AB - Objective: Investigate the association of dispositional optimism with chronic kidney disease (CKD) and rapid kidney function decline (RKFD) and determine if there is modification by age, sex, and educational attainment among African Americans. Methods: Optimism was measured using the 6-item Life Orientation Test-Revised scale (categorized into tertiles and log transformed) among participants from the Jackson Heart Study (n = 1960). CKD was defined as the presence of albuminuria or reduced glomerular filtration rate of <60 mL/min/1.73m2, or report of dialysis at baseline examination (2000–2004). RKFD was defined as a decline >3 mL/min/1.73m2/year between baseline and exam 3 (2009–2013). The cross-sectional and prospective associations between optimism and kidney outcomes were tested using multivariable logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI), adjusting for demographics, education, risk factors, behaviors, and depressive symptoms. We tested effect modification by age, sex, and education. Results: 569 participants had CKD and 326 were classified as having RKFD by exam 3. After full adjustment, the OR for CKD was 0.73 for those who reported high (vs. low) optimism (95% CI 0.55–0.99) and 0.56 (95% CI 0.27–1.15) for the optimism score. After 7.21 median years of follow up, the OR for RKFD was 0.51 for those who reported high (vs. low) optimism (95% CI 0.34–0.76), and 0.26 (95% CI 0.10–0.56) for the optimism score, after full adjustment. There was no evidence of effect modification by demographics or educational attainment. Conclusions: Higher optimism was associated with a lower odds of CKD and a lower odds of RKFD.
KW - African Americans
KW - Chronic kidney disease
KW - Jackson heart study
KW - Optimism
KW - Rapid kidney function decline
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U2 - 10.1016/j.jpsychores.2020.110267
DO - 10.1016/j.jpsychores.2020.110267
M3 - Article
C2 - 33069050
AN - SCOPUS:85092523350
SN - 0022-3999
VL - 139
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 110267
ER -