TY - JOUR
T1 - Optimism is associated with chronic kidney disease and rapid kidney function decline among African Americans in the Jackson Heart Study
AU - Glover, LáShauntá M.
AU - Butler-Williams, Crystal
AU - Cain-Shields, Loretta
AU - Forde, Allana T.
AU - Purnell, Tanjala S.
AU - Young, Bessie
AU - Sims, Mario
N1 - Funding Information:
The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I) and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). Dr. Sims was also supported by the JHS contract and grants 15SFDRN26140001 from the American Heart Association and 1R01HL135200 from the NHLBI. Ms. Glover is supported by the Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GENHLB) T32 HL129982. Dr. Purnell is supported in part by the Agency for Healthcare Research and Quality. Dr. Young is supported in part by the Veterans Affairs Puget Sound Health Care System. Dr. Forde is supported by the Division of Intramural Research of the National Institute on Minority Health and Health Disparities of the National Institutes of Health.
Funding Information:
The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University ( HHSN268201800013I ), Tougaloo College ( HHSN268201800014I ), the Mississippi State Department of Health ( HHSN268201800015I ) and the University of Mississippi Medical Center ( HHSN268201800010I , HHSN268201800011I and HHSN268201800012I ) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). Dr. Sims was also supported by the JHS contract and grants 15SFDRN26140001 from the American Heart Association and 1R01HL135200 from the NHLBI . Ms. Glover is supported by the Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GENHLB) T32 HL129982 . Dr. Purnell is supported in part by the Agency for Healthcare Research and Quality . Dr. Young is supported in part by the Veterans Affairs Puget Sound Health Care System . Dr. Forde is supported by the Division of Intramural Research of the National Institute on Minority Health and Health Disparities of the National Institutes of Health .
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - Objective: Investigate the association of dispositional optimism with chronic kidney disease (CKD) and rapid kidney function decline (RKFD) and determine if there is modification by age, sex, and educational attainment among African Americans. Methods: Optimism was measured using the 6-item Life Orientation Test-Revised scale (categorized into tertiles and log transformed) among participants from the Jackson Heart Study (n = 1960). CKD was defined as the presence of albuminuria or reduced glomerular filtration rate of <60 mL/min/1.73m2, or report of dialysis at baseline examination (2000–2004). RKFD was defined as a decline >3 mL/min/1.73m2/year between baseline and exam 3 (2009–2013). The cross-sectional and prospective associations between optimism and kidney outcomes were tested using multivariable logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI), adjusting for demographics, education, risk factors, behaviors, and depressive symptoms. We tested effect modification by age, sex, and education. Results: 569 participants had CKD and 326 were classified as having RKFD by exam 3. After full adjustment, the OR for CKD was 0.73 for those who reported high (vs. low) optimism (95% CI 0.55–0.99) and 0.56 (95% CI 0.27–1.15) for the optimism score. After 7.21 median years of follow up, the OR for RKFD was 0.51 for those who reported high (vs. low) optimism (95% CI 0.34–0.76), and 0.26 (95% CI 0.10–0.56) for the optimism score, after full adjustment. There was no evidence of effect modification by demographics or educational attainment. Conclusions: Higher optimism was associated with a lower odds of CKD and a lower odds of RKFD.
AB - Objective: Investigate the association of dispositional optimism with chronic kidney disease (CKD) and rapid kidney function decline (RKFD) and determine if there is modification by age, sex, and educational attainment among African Americans. Methods: Optimism was measured using the 6-item Life Orientation Test-Revised scale (categorized into tertiles and log transformed) among participants from the Jackson Heart Study (n = 1960). CKD was defined as the presence of albuminuria or reduced glomerular filtration rate of <60 mL/min/1.73m2, or report of dialysis at baseline examination (2000–2004). RKFD was defined as a decline >3 mL/min/1.73m2/year between baseline and exam 3 (2009–2013). The cross-sectional and prospective associations between optimism and kidney outcomes were tested using multivariable logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI), adjusting for demographics, education, risk factors, behaviors, and depressive symptoms. We tested effect modification by age, sex, and education. Results: 569 participants had CKD and 326 were classified as having RKFD by exam 3. After full adjustment, the OR for CKD was 0.73 for those who reported high (vs. low) optimism (95% CI 0.55–0.99) and 0.56 (95% CI 0.27–1.15) for the optimism score. After 7.21 median years of follow up, the OR for RKFD was 0.51 for those who reported high (vs. low) optimism (95% CI 0.34–0.76), and 0.26 (95% CI 0.10–0.56) for the optimism score, after full adjustment. There was no evidence of effect modification by demographics or educational attainment. Conclusions: Higher optimism was associated with a lower odds of CKD and a lower odds of RKFD.
KW - African Americans
KW - Chronic kidney disease
KW - Jackson heart study
KW - Optimism
KW - Rapid kidney function decline
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U2 - 10.1016/j.jpsychores.2020.110267
DO - 10.1016/j.jpsychores.2020.110267
M3 - Article
C2 - 33069050
AN - SCOPUS:85092523350
SN - 0022-3999
VL - 139
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 110267
ER -