Optimal Treatment of Depression and Anxiety in Parkinson's Disease

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Depression and anxiety are highly prevalent and have major adverse effects on function and quality of life in Parkinson's disease (PD). Optimal management requires that motor symptoms and psychiatric symptoms be simultaneously addressed. While there is fairly robust evidence for the treatment of motor symptoms, there are no completed randomized controlled trials to guide pharmacological treatment of anxiety in PD and no nonpharmacologic interventions have proven efficacious. Several high-quality trials for depression in PD suggest a number of antidepressants and cognitive behavioral therapy may help, but there is no data on rates of recurrence, comparative efficacy, or augmentation strategies. In order to address the gaps in knowledge, the authors provide a summary of the current evidence for treating depression and anxiety in PD and offer an algorithm that extends beyond the current literature based on clinical experience working in a multidisciplinary specialty center.

Original languageEnglish (US)
Pages (from-to)530-540
Number of pages11
JournalAmerican Journal of Geriatric Psychiatry
Issue number6
StatePublished - Jun 2021


  • Parkinson's disease
  • anxiety
  • depression
  • treatment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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