Optimal surgical management of severe ischemic mitral regurgitation: To repair or to replace?

Louis P. Perrault, Alan J. Moskowitz, Irving L. Kron, Michael A. Acker, Marissa A. Miller, Keith A. Horvath, Vinod H. Thourani, Michael Argenziano, David A. D'Alessandro, Eugene H. Blackstone, Claudia S. Moy, Joseph P. Mathew, Judy Hung, Timothy J. Gardner, Michael K. Parides

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Background: Ischemic mitral regurgitation, a complication of myocardial infarction and coronary artery disease more generally, is associated with a high mortality rate and is estimated to affect 2.8 million Americans. With 1-year mortality rates as high as 40%, recent practice guidelines of professional societies recommend repair or replacement, but there remains a lack of conclusive evidence supporting either intervention. The choice between therapeutic options is characterized by the trade-off between reduced operative morbidity and mortality with repair versus a better long-term correction of mitral insufficiency with replacement. The long-term benefits of repair versus replacement remain unknown, which has led to significant variation in surgical practice. Methods and Results: This article describes the design of a prospective randomized clinical trial to evaluate the safety and effectiveness of mitral valve repair and replacement in patients with severe ischemic mitral regurgitation. This trial is being conducted as part of the Cardiothoracic Surgical Trials Network. This article addresses challenges in selecting a feasible primary end point, characterizing the target population (including the degree of mitral regurgitation) and analytical challenges in this high mortality disease. Conclusions: The article concludes by discussing the importance of information on functional status, survival, neurocognition, quality of life, and cardiac physiology in therapeutic decision making.

Original languageEnglish (US)
Pages (from-to)1396-1403
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number6
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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