OPTIMAL CONTROL OF DRUG ADMINISTRATION.

Hideo Kusuoka; Shinzo Kodama; Masatsugu Hori; Michitoshi Inoue; Hiroshi Abe; Fumihiko Kajiya

OPTIMAL CONTROL OF DRUG ADMINISTRATION.

Hideo Kusuoka, Shinzo Kodama, Masatsugu Hori, Michitoshi Inoue, Hiroshi Abe, Fumihiko Kajiya

School of Medicine

Research output: Contribution to conference › Paper › peer-review

6 Scopus citations

Abstract

This paper considers optimalization of drug administration as an optimal impulsive control of a compartmental system. That is, a linear compartmental system is employed as model for evaluating drug distribution in the human body and the oral administration of the drug is considered as an impulsive input to the system. The first problem considered in this paper is the construction of the model. The model is assumed to contain either two or three compartments. The optimal administration program is considered for ABPC (one of the antibiotics) and digoxin (one of the heart medicines). In administration of the constant dose at regular time-intervals, an approximate relation between the optimal dose and the time-interval is obtained.

Original language	English (US)
Pages	63-68
Number of pages	6
State	Published - Jan 1 1978
Event	Proc Int Conf Cybern Soc Tokyo, Jpn, Nov 3-5 - Kyoto, Jpn Duration: Nov 7 1978 → Nov 7 1978

Other

Other	Proc Int Conf Cybern Soc Tokyo, Jpn, Nov 3-5
City	Kyoto, Jpn
Period	11/7/78 → 11/7/78

ASJC Scopus subject areas

General Engineering

Cite this

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title = "OPTIMAL CONTROL OF DRUG ADMINISTRATION.",

abstract = "This paper considers optimalization of drug administration as an optimal impulsive control of a compartmental system. That is, a linear compartmental system is employed as model for evaluating drug distribution in the human body and the oral administration of the drug is considered as an impulsive input to the system. The first problem considered in this paper is the construction of the model. The model is assumed to contain either two or three compartments. The optimal administration program is considered for ABPC (one of the antibiotics) and digoxin (one of the heart medicines). In administration of the constant dose at regular time-intervals, an approximate relation between the optimal dose and the time-interval is obtained.",

author = "Hideo Kusuoka and Shinzo Kodama and Masatsugu Hori and Michitoshi Inoue and Hiroshi Abe and Fumihiko Kajiya",

year = "1978",

month = jan,

day = "1",

language = "English (US)",

pages = "63--68",

note = "Proc Int Conf Cybern Soc Tokyo, Jpn, Nov 3-5 ; Conference date: 07-11-1978 Through 07-11-1978",

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TY - CONF

T1 - OPTIMAL CONTROL OF DRUG ADMINISTRATION.

AU - Kusuoka, Hideo

AU - Kodama, Shinzo

AU - Hori, Masatsugu

AU - Inoue, Michitoshi

AU - Abe, Hiroshi

AU - Kajiya, Fumihiko

PY - 1978/1/1

Y1 - 1978/1/1

N2 - This paper considers optimalization of drug administration as an optimal impulsive control of a compartmental system. That is, a linear compartmental system is employed as model for evaluating drug distribution in the human body and the oral administration of the drug is considered as an impulsive input to the system. The first problem considered in this paper is the construction of the model. The model is assumed to contain either two or three compartments. The optimal administration program is considered for ABPC (one of the antibiotics) and digoxin (one of the heart medicines). In administration of the constant dose at regular time-intervals, an approximate relation between the optimal dose and the time-interval is obtained.

AB - This paper considers optimalization of drug administration as an optimal impulsive control of a compartmental system. That is, a linear compartmental system is employed as model for evaluating drug distribution in the human body and the oral administration of the drug is considered as an impulsive input to the system. The first problem considered in this paper is the construction of the model. The model is assumed to contain either two or three compartments. The optimal administration program is considered for ABPC (one of the antibiotics) and digoxin (one of the heart medicines). In administration of the constant dose at regular time-intervals, an approximate relation between the optimal dose and the time-interval is obtained.

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M3 - Paper

AN - SCOPUS:0018106285

SP - 63

EP - 68

T2 - Proc Int Conf Cybern Soc Tokyo, Jpn, Nov 3-5

Y2 - 7 November 1978 through 7 November 1978

ER -

OPTIMAL CONTROL OF DRUG ADMINISTRATION.

Abstract

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ASJC Scopus subject areas

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