TY - JOUR
T1 - Optimal adaptive electrode selection to maximize simultaneously recorded neuron yield
AU - Choi, John
AU - Kumar, Krishan
AU - Khazali, Mohammad
AU - Wingel, Katie
AU - Choudhury, Mahdi
AU - Charles, Adam
AU - Pesaran, Bijan
N1 - Funding Information:
This work was supported in part by an award from the Simons Foundation (SCGB Award 325548), the National Institutes for Health (R01-NS104923, U01-NS0990577, U01-NS103518), the Army Research Office (68984-CS-MUR) and the Defense Advanced Research Projects Agency (N66001-17-C-4002).
Publisher Copyright:
© 2020 Neural information processing systems foundation. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Neural-Matrix style, high-density electrode arrays for brain-machine interfaces (BMIs) and neuroscientific research require the use of multiplexing: Each recording channel can be routed to one of several electrode sites on the array. This capability allows the user to flexibly distribute recording channels to the locations where the most desirable neural signals can be resolved. For example, in the Neuropixel probe, 960 electrodes can be addressed by 384 recording channels. However, currently no adaptive methods exist to use recorded neural data to optimize/customize the electrode selections per recording context. Here, we present an algorithm called classification-based selection (CBS) that optimizes the joint electrode selections for all recording channels so as to maximize isolation quality of detected neurons. We show, in experiments using Neuropixels in non-human primates, that this algorithm yields a similar number of isolated neurons as would be obtained if all electrodes were recorded simultaneously. Neuron counts were 41-85% improved over previously published electrode selection strategies. The neurons isolated from electrodes selected by CBS were a 73% match, by spike timing, to the complete set of recordable neurons around the probe. The electrodes selected by CBS exhibited higher average per-recording-channel signal-to-noise ratio. CBS, and selection optimization in general, could play an important role in development of neurotechnologies for BMI, as signal bandwidth becomes an increasingly limiting factor.
AB - Neural-Matrix style, high-density electrode arrays for brain-machine interfaces (BMIs) and neuroscientific research require the use of multiplexing: Each recording channel can be routed to one of several electrode sites on the array. This capability allows the user to flexibly distribute recording channels to the locations where the most desirable neural signals can be resolved. For example, in the Neuropixel probe, 960 electrodes can be addressed by 384 recording channels. However, currently no adaptive methods exist to use recorded neural data to optimize/customize the electrode selections per recording context. Here, we present an algorithm called classification-based selection (CBS) that optimizes the joint electrode selections for all recording channels so as to maximize isolation quality of detected neurons. We show, in experiments using Neuropixels in non-human primates, that this algorithm yields a similar number of isolated neurons as would be obtained if all electrodes were recorded simultaneously. Neuron counts were 41-85% improved over previously published electrode selection strategies. The neurons isolated from electrodes selected by CBS were a 73% match, by spike timing, to the complete set of recordable neurons around the probe. The electrodes selected by CBS exhibited higher average per-recording-channel signal-to-noise ratio. CBS, and selection optimization in general, could play an important role in development of neurotechnologies for BMI, as signal bandwidth becomes an increasingly limiting factor.
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M3 - Conference article
AN - SCOPUS:85108431591
SN - 1049-5258
VL - 2020-December
JO - Advances in Neural Information Processing Systems
JF - Advances in Neural Information Processing Systems
T2 - 34th Conference on Neural Information Processing Systems, NeurIPS 2020
Y2 - 6 December 2020 through 12 December 2020
ER -