Optical phase modulation by natural eye movements: application to time-domain FF-OCT image retrieval

Viacheslav Mazlin, Peng Xiao, Kristina Irsch, Jules Scholler, Kassandra Groux, Kate Grieve, Mathias Fink, A. Claude Boccara

Research output: Contribution to journalArticlepeer-review


Eye movements are commonly seen as an obstacle to high-resolution ophthalmic imaging. In this context we study the natural axial movements of the in vivo human eye and show that they can be used to modulate the optical phase and retrieve tomographic images via time-domain full-field optical coherence tomography (TD-FF-OCT). This approach opens a path to a simplified ophthalmic TD-FF-OCT device, operating without the usual piezo motor-camera synchronization. The device demonstrates in vivo human corneal images under the different image retrieval schemes (2-phase and 4-phase) and different exposure times (3.5 ms, 10 ms, 20 ms). Data on eye movements, acquired with a spectral-domain OCT with axial eye tracking (180 B-scans/s), are used to study the influence of ocular motion on the probability of capturing high-signal tomographic images without phase washout. The optimal combinations of camera acquisition speed and amplitude of piezo modulation are proposed and discussed.

Original languageEnglish (US)
Pages (from-to)902-920
Number of pages19
JournalBiomedical Optics Express
Issue number2
StatePublished - Feb 1 2022
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology


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