Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules

Naomi R. Goldberg, Douglas A. Jabs, Jacqueline Busingye

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Abstract: Purpose: To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis. Methods: This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy. Results: Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After treatment with corticosteroids and/or immunosuppression in 4 followed patients, all lesions regressed with improvement in associated structural changes, but did not entirely disappear. Conclusions: Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalOcular Immunology and Inflammation
Issue number3
StatePublished - May 3 2016


  • Granuloma
  • OCT
  • nodule
  • optic nerve
  • retina
  • sarcoidosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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